[铁磁性药物载体颗粒在微血管中的靶向聚集特性研究]
[A study on the targeting collect character of ferromagnetic drug carrier particles in microvasculature].
作者信息
Li Xinxia, Guo Ping, Chen You, Xiong Ping
机构信息
School of Nuclear Science and Technology, University of South China, Hengyang 421001, China.
出版信息
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2010 Jun;27(3):533-7.
The transport and capture of therapeutic magnetic particles in the human microvasculature is studied numerically. Taking into account the dominant magnetic and fluidic forces on the particles, we have shown in our study that the particles can be directed to and concentrated at the desired zone which is within a few centimeters from the surface of the body. In addition, we have analyzed the influences of the malignant tissue depth, of the nanometers-iron nuclide content in a particle, and of the blood flow velocity and blood vessel diameter upon the captured efficiency.
对治疗性磁性颗粒在人体微血管中的运输和捕获进行了数值研究。考虑到颗粒上主要的磁力和流体力，我们在研究中表明，颗粒可以被引导至并集中在距身体表面几厘米范围内的所需区域。此外，我们分析了恶性组织深度、颗粒中纳米铁核素含量、血流速度和血管直径对捕获效率的影响。
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