Burodom Anyanee
Division of Physiology, Institute of Preclinical Science, Faculty of Medicine, Thammasat University, Prathumthani, Thailand.
J Med Assoc Thai. 2010 Jul;93(7):824-9.
Renal disease has progressively affected Thai people. Protein diet has been well documented to induce renal hyper-filtration. Therefore, recommendation to patients with kidney disease should be clear. Egg white is indicated as complete protein. However, comparative study of its effect on renal function with protein of animal meat has been rarely reported.
Evaluate renal response to egg white protein load as compared to chicken protein load.
High protein loading from different sources was evaluated in 11 healthy volunteers. They were enrolled in two separate experiments conducted within 1-week interval. Baseline GFR was examined by 24 hour C(cr) before each protein challenge. Then the subject randomly received a protein rich meal of 0.8 g/Kg x BW of steamed egg white or boiled chicken breast. The spot C(cr) was performed every 60 minutes for 3 hours for finding peak GFR after high protein intake.
Baseline GFR of both experiments was not different. After two protein meals, GFR was significantly increased and reached the peak values at 60 minutes. There was no difference of peak GFR between both protein sources. The renal reserve was indicated as 64% and 58% increments from baseline values in egg white and chicken protein respectively.
In normal subjects, egg white protein stimulated as high renal response as chicken protein when challenged with the same amount of protein.
肾脏疾病在泰国人群中的影响日益加重。高蛋白饮食已被充分证明会引发肾脏高滤过。因此，对于肾病患者的饮食建议应明确。蛋清被视为完全蛋白质。然而，关于其对肾功能的影响与动物肉类蛋白质的比较研究鲜有报道。
评估与鸡肉蛋白负荷相比，蛋清蛋白负荷对肾脏的反应。
在11名健康志愿者中评估不同来源的高蛋白负荷。他们参加了在1周间隔内进行的两项独立实验。在每次蛋白质激发前，通过24小时肌酐清除率（C(cr)）检测基线肾小球滤过率（GFR）。然后受试者随机接受0.8 g/Kg×体重的蒸蛋清或煮鸡胸肉的高蛋白餐。在高蛋白摄入后，每60分钟进行一次即时C(cr)检测，持续3小时以寻找GFR峰值。
两项实验的基线GFR无差异。两次蛋白质餐后，GFR显著升高并在60分钟时达到峰值。两种蛋白质来源的GFR峰值无差异。蛋清和鸡肉蛋白的肾脏储备分别表示为相对于基线值增加64%和58%。
在正常受试者中，当给予相同量的蛋白质时，蛋清蛋白刺激的肾脏反应与鸡肉蛋白一样高。
