Nachajski Michal Jakub, Zgoda Marian Mikołaj
Drug Form Technology Unit, Department of Applied Pharmacy, Medical University in Łodz.
Polim Med. 2010;40(2):65-77.
Pre-formulation research was conducted on the application of Ex. Echinaceae aq. siccum in the production of a quickly disintegrating suspension tablet, a lozenge with kariostatic sugar alcohols (mannitol, sorbitol), and, above all, a solid drug form with controlled release of therapeutic agents included in the extract. Morphological parameters of tablets obtained in the course of experiment were estimated and the profiles of the release (diffusion) ofhydrophilic therapeutic agents into model receptor fluids with varying values of osmolarity (0.1 mol HCl approximately 200 mOsm/l, hypotonic hydrating fluid approximately 143 mOsm/l, and compensatory paediatric fluid approximately 272 mOsm/l) were examined. The study focused on the technological problem of determining the effect of hydrogel Carbopol structure on the ordering of diffusion ofhydrophilic therapeutic agents from a model drug form (a tablet) into model fluids with variable osmolarity.
针对紫锥菊干浸膏在速崩性混悬片、含抑龋糖醇（甘露醇、山梨醇）的含片以及最重要的含提取物中治疗剂控释的固体剂型生产中的应用进行了处方前研究。对实验过程中获得的片剂的形态学参数进行了评估，并研究了亲水性治疗剂在不同渗透压值（0.1 mol HCl约200 mOsm/l、低渗补液约143 mOsm/l和小儿补充液约272 mOsm/l）的模型受体液中的释放（扩散）曲线。该研究聚焦于确定水凝胶卡波姆结构对亲水性治疗剂从模型药物剂型（片剂）扩散到不同渗透压的模型流体中的有序性的影响这一技术问题。
