Tianjin Key Laboratory of Exercise Physiology and Sports Medicine, Department of Health and Exercise Science, Tianjin University of Sport, Tianjin, China.
Ann N Y Acad Sci. 2010 Jul;1201:121-8. doi: 10.1111/j.1749-6632.2010.05618.x.
Exercise induced adaptations in muscle are highly specific and dependent upon the type of exercise, as well as its frequency, intensity, and duration. Mitochondria are highly dynamic organelles. Fusion and fission reactions lead to a continuous remodeling of the mitochondrial network, which range from reticulum of elongated and branched filaments to collections of individual organelles. Mitochondrial network dynamics are sensitive to various physiological and pathological stimuli, and mitochondrial morphological changes are no epiphenomena, but central to cell function and survival. There is a strong correlation between mitochondrial network morphology, dynamic-related protein, and energy metabolism. It is expected that alteration in cellular energy status during exercise can also be achieved through mitochondrial network dynamics. In this review, we describe mitochondrial network remodeling response to acute and endurance exercise, which is accompanied by bioenergetics and redox regulation. In addition, potential mechanisms for metabolic and redox signaling involved in mitochondrial dynamic regulation are also reviewed.
运动引起的肌肉适应性具有高度特异性，取决于运动的类型，以及其频率、强度和持续时间。线粒体是高度动态的细胞器。融合和裂变反应导致线粒体网络的持续重塑，从伸长和分支丝状的网到单个细胞器的集合。线粒体网络动力学对各种生理和病理刺激敏感，线粒体形态变化不是偶然现象，而是细胞功能和存活的核心。线粒体网络形态、动态相关蛋白和能量代谢之间存在很强的相关性。预计运动期间细胞能量状态的改变也可以通过线粒体网络动力学来实现。在这篇综述中，我们描述了急性和耐力运动对线粒体网络重塑的反应，这伴随着生物能量学和氧化还原调节。此外，还回顾了涉及线粒体动态调节的代谢和氧化还原信号的潜在机制。
