来氟米特与霉酚酸酯治疗表现为肾病综合征的免疫球蛋白A肾病的疗效比较。
Comparison of the therapeutic effects of leflunomide and mycophenolate mofetil in the treatment of immunoglobulin A nephropathy manifesting with nephrotic syndrome.
作者信息
Liu X W, Li D M, Xu G S, Sun S R
机构信息
Department of Nephrology, and 2Information Section, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
出版信息
Int J Clin Pharmacol Ther. 2010 Aug;48(8):509-13. doi: 10.5414/cpp48509.
OBJECTIVE
To evaluate the therapeutic effects and safety of a combination therapy of leflunomide (LEF) and prednisone for the treatment of immunoglobulin A (IgA) nephropathy manifesting with nephrotic syndrome.
METHODS
40 patients with IgA nephropathy manifesting with nephrotic syndrome were randomly divided into two groups. The treatment group was administered with a combination therapy of prednisone and LEF, and the control group with a combination therapy of prednisone and MMF. For the following comparison 24-h urinary protein excretion and the serum levels of albumin, cholesterol, and creatinine before and after the therapy were assessed.
RESULTS
In the treatment group, the medication was markedly effective in 5 cases and effective in 7 cases; the total efficacy rate was 60.0%. In the control group, the treatment was markedly effective in 5 cases and effective in 8 cases; the total efficacy rate was 65.0%. The IgA levels in both groups decreased after therapy. There were no significant differences between the results for the two groups (p > 0.05). The treatments were well tolerated in both groups.
CONCLUSION
LEF is a safe and effective drug for the treatment of IgA nephropathy manifesting with nephrotic syndrome.
目的
评估来氟米特（LEF）联合泼尼松治疗表现为肾病综合征的免疫球蛋白A（IgA）肾病的疗效及安全性。
方法
将40例表现为肾病综合征的IgA肾病患者随机分为两组。治疗组给予泼尼松联合LEF治疗，对照组给予泼尼松联合霉酚酸酯（MMF）治疗。评估治疗前后24小时尿蛋白排泄量以及血清白蛋白、胆固醇和肌酐水平以进行组间比较。
结果
治疗组中，显效5例，有效7例；总有效率为60.0%。对照组中，显效5例，有效8例；总有效率为65.0%。两组治疗后IgA水平均下降。两组结果之间无显著差异（p>0.05）。两组对治疗的耐受性均良好。
结论
LEF是治疗表现为肾病综合征的IgA肾病的一种安全有效的药物。
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