Medical Research Unit in Clinical Epidemiology, Specialties Hospital, Medical Unit of High Specialty, West National Medical Center, Mexican Institute of Social Security, 44349 Guadalajara, Mexico.
Nutr Res. 2010 Jun;30(6):392-5. doi: 10.1016/j.nutres.2010.06.005.
In accordance with obesity is associated with insulin resistance and dyslipidemia and chitosan decrease weight and lipids, but its effect on insulin sensitivity is unknown. Our hypothesis for the research was that chitosan improves insulin sensitivity estimated with the euglycemic-hyperinsulinemic clamp technique in obesity. We undertook this study with the objective to determine the effect of chitosan on insulin sensitivity using the euglycemic-hyperinsulinemic clamp technique in obese patients during a 3-month period. A randomized, double-blind clinical trial was carried out in 12 obese adults without diabetes mellitus. During a 3-month period, 6 patients received chitosan (750 mg, 3 times per day) 30 minutes before meals, and the other 6 subjects received placebo. Serum glucose, total cholesterol, high-density lipoprotein cholesterol, and triglycerides (TG) were measured. Insulin sensitivity was estimated with the euglycemic-hyperinsulinemic clamp technique before and after the intervention. Insulin sensitivity increased significantly with the administration of chitosan (2.4 +/- 1.4 vs 3.6 +/- 1.4 mg kg(-1) min(-1); P = .043). In addition, there was a decrease in weight (90.7 +/- 14.2 vs 84.7 +/- 13.7 kg; P = .027), body mass index (34.3 +/- 2.7 vs 31.6 +/- 2.2 kg/m(2); P = .028), waist circumference (106 +/- 12 vs 99 +/- 9 cm; P = .028) and TG (2.4 +/- 0.9 vs 1.6 +/- 0.9 mmol/L; P = .028) in the chitosan group. In conclusion, 3-month administration of chitosan increased insulin sensitivity in obese patients and demonstrated a decrease in weight, body mass index, waist circumference, and TG.
根据肥胖与胰岛素抵抗和血脂异常有关，壳聚糖可降低体重和血脂，但对胰岛素敏感性的影响尚不清楚。我们的研究假设是壳聚糖通过正葡萄糖高胰岛素钳夹技术改善肥胖患者的胰岛素敏感性。我们进行这项研究的目的是在 3 个月的时间内，通过正葡萄糖高胰岛素钳夹技术确定壳聚糖对肥胖患者胰岛素敏感性的影响。一项随机、双盲临床试验在 12 名无糖尿病的肥胖成年人中进行。在 3 个月的时间里，6 名患者在饭前 30 分钟服用壳聚糖（750mg，每天 3 次），另外 6 名患者服用安慰剂。检测血清葡萄糖、总胆固醇、高密度脂蛋白胆固醇和甘油三酯（TG）。在干预前后用正葡萄糖高胰岛素钳夹技术估计胰岛素敏感性。服用壳聚糖后，胰岛素敏感性显著增加（2.4 ± 1.4 对 3.6 ± 1.4mg/kg/min；P =.043）。此外，体重（90.7 ± 14.2 对 84.7 ± 13.7kg；P =.027）、体重指数（34.3 ± 2.7 对 31.6 ± 2.2kg/m2；P =.028）、腰围（106 ± 12 对 99 ± 9cm；P =.028）和 TG（2.4 ± 0.9 对 1.6 ± 0.9mmol/L；P =.028）在壳聚糖组中均有下降。总之，3 个月的壳聚糖治疗可增加肥胖患者的胰岛素敏感性，并可降低体重、体重指数、腰围和 TG。
