Raymond F, Datta H, Moss D
Department of Chemical Pathology, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.
Biochim Biophys Acta. 1991 Jul 8;1074(2):217-22. doi: 10.1016/0304-4165(91)90155-a.
Alkaline phosphatase is anchored to cell membranes by a glycosyl-phosphatidylinositol anchor and is present in bile and plasma in various isoforms. The formation of these isoforms depends upon mechanisms of release and subsequent complex formation. Evidence is presented for an enzymatic activity possibly a glycosyl-phosphatidylinositol-specific phospholipase D (GPI-PLD), in serum that releases an isoform incapable of further complex formation, whereas such an activity is absent from bile.
碱性磷酸酶通过糖基磷脂酰肌醇锚定在细胞膜上，并以多种同工型存在于胆汁和血浆中。这些同工型的形成取决于释放机制和随后的复合物形成。有证据表明，血清中存在一种酶活性，可能是一种糖基磷脂酰肌醇特异性磷脂酶D（GPI-PLD），它能释放出一种无法进一步形成复合物的同工型，而胆汁中则不存在这种活性。
