Miao Yun, Yu Li-xin, Deng Wen-feng, Fu Shao-jie, Xu Jian, Du Chuan-fu, Wang Yi-bin, Ye Gui-rong, Hu Ping
Department of Organ Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2010 Jul;30(7):1679-81.
To summarize the features of pulmonary infection (PI) in kidney transplant (Ktx) and liver transplant (Ltx) recipients for effective control measures.
A retrospective analysis was conducted among Ktx recipients and Ltx recipients with PI during the period from Jan 2004 to Dec 2008. The clinical data concerning the infection was compared.
Forty-five Ktx recipients and 23 Ltx recipients developed PI after the transplantation. The incidence of PI was 7.4% and 56.1% in (P<0.001), respectively, with severe PI occurring in 2.6% and 46.3% of the recipients (P<0.001). The median time from PI diagnosis to transplant was 230 days (29-1080 days) and 4 days (2-104 days) (P<0.001), the case-fatality rate for PI was 6.7% and 17.4% (P=NS), and the mortality rate was 0.5% and 9.8% (P<0.001) in Ktx and Ltx recipients, respectively; Gram-negative organisms were the most common in both Ktx and Ltx recipients, but Ltx recipients had significantly higher incidence of multidrug-resistant bacteria (12.9% vs 37.0%, P=0.005).
The knowledge of PI after the transplantation will benefit appropriate prophylactic and empirical treatment to improve the survival of Ktx and Ltx recipients.
总结肾移植（Ktx）和肝移植（Ltx）受者肺部感染（PI）的特征，以制定有效的控制措施。
对2004年1月至2008年12月期间发生PI的Ktx受者和Ltx受者进行回顾性分析。比较感染的临床数据。
45例Ktx受者和23例Ltx受者移植后发生PI。PI的发生率分别为7.4%和56.1%（P<0.001），严重PI分别发生在2.6%和46.3%的受者中（P<0.001）。PI诊断至移植的中位时间分别为230天（29 - 1080天）和4天（2 - 104天）（P<0.001），PI的病死率分别为6.7%和17.4%（P=无显著性差异），Ktx和Ltx受者的死亡率分别为0.5%和9.8%（P<0.001）；革兰氏阴性菌在Ktx和Ltx受者中均最常见，但Ltx受者多重耐药菌的发生率显著更高（12.9%对37.0%，P=0.005）。
了解移植后PI的情况将有助于采取适当的预防和经验性治疗，以提高Ktx和Ltx受者的生存率。
