International Research and Educational Institute for Integrated Medical Sciences (IREIIMS), Tokyo Women's Medical University, Tokyo, Japan.
Anticancer Res. 2010 Jun;30(6):2347-9.
Gastric atrophy caused by Helicobacter pylori (H. pylori) infection is a risk factor for gastric cancer. We aimed to evaluate the relationship between gastric cancer risk and tumor markers in the general population.
A total of 688 volunteers were examined to test their serum pepsinogen (PG) levels and anti-H. pylori antibodies, in addition to a total of 22 serum tumor markers. The participants were classified into four groups according to their anti-H. pylori antibody and serum PG serological status. Accordingly, groups A and D were negative, whereas groups B and C were positive for anti-H. pylori antibodies; and groups A and B were normal, whereas groups C and D were abnormal for serum PG levels. All the blood examination results were statistically evaluated using Student's t-test among these groups.
There were 424, 202, 50, and 12 individuals in groups A, B, C, and D, respectively. Because of the small number of participants in groups C and D, we combined these two groups. Compared to the normal group (A), a statistically significant higher in adenosine deaminase level was found in group C+D (p=0.01).
This result supports a previous study indicating that adenosine deaminase is involved in the regulatory system of chronic atrophic gastritis and gastric cancer risk.
幽门螺杆菌（H. pylori）感染引起的胃萎缩是胃癌的危险因素。我们旨在评估一般人群中胃癌风险与肿瘤标志物之间的关系。
对 688 名志愿者进行了检查，以检测其血清胃蛋白酶原（PG）水平和抗 H. pylori 抗体，此外还检测了 22 种血清肿瘤标志物。根据抗 H. pylori 抗体和血清 PG 血清学状态，将参与者分为四组。因此，组 A 和 D 为阴性，而组 B 和 C 为抗 H. pylori 抗体阳性；组 A 和 B 为正常，而组 C 和 D 为血清 PG 水平异常。使用学生 t 检验对这些组之间的所有血液检查结果进行了统计学评估。
A、B、C 和 D 组分别有 424、202、50 和 12 人。由于 C 组和 D 组的参与者人数较少，我们将这两组合并。与正常组（A）相比，C+D 组的腺苷脱氨酶水平明显升高（p=0.01）。
这一结果支持先前的研究表明，腺苷脱氨酶参与慢性萎缩性胃炎和胃癌风险的调节系统。
