Lauer C J, Riemann D, Wiegand M, Berger M
Max-Planck-Institute for Psychiatry, Munich, Germany.
Biol Psychiatry. 1991 May 15;29(10):979-93. doi: 10.1016/0006-3223(91)90355-p.
In order to evaluate the impact of aging on EEG sleep patterns we investigated the polysomnograms of 74 patients with major depression and 51 healthy volunteers aged 18-65 years. In most of the EEG sleep parameters, age-related changes were obvious in both the depressives and the normals. In the patients, some of these alterations occurred earlier and were more pronounced. The amount of slow-wave sleep decreased with age, but no differences were found between the depressives and the healthy volunteers at any particular age. Rapid-eye-movement (REM) latency was clearly affected by age, but there were no significant differences between patients and controls until the middle of the fourth decade of life. On the other hand, REM density measures did not vary with age and were increased in the depressives. Therefore, REM density appears to be a more likely candidate for a biologic marker for major depression than is REM latency.
为了评估衰老对脑电图睡眠模式的影响，我们调查了74例重度抑郁症患者和51名年龄在18至65岁之间的健康志愿者的多导睡眠图。在大多数脑电图睡眠参数方面，抑郁症患者和正常人群中与年龄相关的变化都很明显。在患者中，其中一些变化出现得更早且更明显。慢波睡眠量随年龄减少，但在任何特定年龄的抑郁症患者和健康志愿者之间均未发现差异。快速眼动（REM）潜伏期明显受年龄影响，但在生命的第四个十年中期之前，患者与对照组之间没有显著差异。另一方面，REM密度测量值不随年龄变化，且在抑郁症患者中增加。因此，与REM潜伏期相比，REM密度似乎更有可能成为重度抑郁症的生物学标志物。
