Hennes M L, Stinnett H O
Dept. of Physiology, Univ. of North Dakota Grand Forks.
Biomed Sci Instrum. 1991;27:113-8.
Blood pressure regulation involves feedback signals from baroreceptors detecting wall strain of arterial sinuses. A research goal is identification of wall viscoelastic properties and associations between elements and baroreceptors. This report presents development of computer-based procedures for control of pressure inputs and recording responses of an in situ carotid sinus. Features include a hydraulic system to generate swept-frequency sinusoidal pressure inputs (0.2 to 200 Hz); measurements of: (i) sinus wall area and vectors of strain using a fiber optic sensor system, (ii) intrasinus pressure using solid state probes, (iii) baroreceptor fiber activity using a unipolar electrode and (iv) algorithms for data archival, frequency domain analysis and transfer function determinations. Data analysis will focus on estimates of wall properties of elasticity (K), viscosity (C), natural frequency (omega w), damping ratio (zeta w), reactive mass (Mw) and relationships to similar properties at tissue-baroreceptor junctions. Computer-based procedures are exemplified with data detailing mechanical properties of the hydraulic system; which is an important prerequisite to analysis of sinus viscoelastic properties.
血压调节涉及来自压力感受器的反馈信号，这些感受器可检测动脉窦的壁应变。一个研究目标是确定壁的粘弹性特性以及各组成部分与压力感受器之间的关联。本报告介绍了用于控制压力输入和记录原位颈动脉窦反应的基于计算机的程序的开发。其特点包括：一个液压系统，用于产生扫频正弦压力输入（0.2至200赫兹）；测量：（i）使用光纤传感器系统测量窦壁面积和应变向量，（ii）使用固态探头测量窦内压力，（iii）使用单极电极测量压力感受器纤维活动，以及（iv）用于数据存档、频域分析和传递函数测定的算法。数据分析将集中于对壁的弹性特性（K）、粘性特性（C）、固有频率（ωw）、阻尼比（ζw）、反应质量（Mw）的估计，以及与组织 - 压力感受器连接处类似特性的关系。基于计算机的程序通过详细说明液压系统机械特性的数据进行举例说明；这是分析窦粘弹性特性的一个重要前提条件。
