Coppe D, Steer M L
Int J Oral Surg. 1978 Feb;7(1):43-51. doi: 10.1016/s0300-9785(78)80011-8.
Certain hormones regulate the activity of their target cells by stimulating adenyl cyclase, which is an enzyme located within the target cell's plasma membrane. Adenyl cyclase catalyzes the formation of cyclic AMP, which is released into the cell and modulates cell functions. In this communication the characteristics of adenyl cyclase are reviewed. The coupling between hormone receptors and this enzyme is discussed as is the ability of agents such as hormones, ATP, magnesium, calcium, guanine nucleotides and prostaglandins to alter cyclase activity. Several diseases that result from derangements of the adenyl cyclase system are known and the molecular bases for these diseases are discussed in this review.
某些激素通过刺激腺苷酸环化酶来调节其靶细胞的活性，腺苷酸环化酶是一种位于靶细胞质膜内的酶。腺苷酸环化酶催化环磷酸腺苷的形成，环磷酸腺苷被释放到细胞中并调节细胞功能。在本通讯中，对腺苷酸环化酶的特性进行了综述。讨论了激素受体与该酶之间的偶联，以及激素、三磷酸腺苷、镁、钙、鸟嘌呤核苷酸和前列腺素等物质改变环化酶活性的能力。已知几种由腺苷酸环化酶系统紊乱引起的疾病，本综述讨论了这些疾病的分子基础。
