Feng D, Wang X, Fulton R, Hutton B, Morris J
Basser Department of Computer Science, University of Sydney, N.S.W., Australia.
Biomed Sci Instrum. 1991;27:43-8.
Tracer kinetic modeling with Positron Emission Tomography (PET) requires measurements of the time-activity curves in both plasma (PTAC) and tissue (TTAC) to estimate physiological parameters. However, the estimation usually ignores the measurement noise in plasma tracer activity curves. The accuracy and reliability of the physiological parameters estimated by ignoring such noise are not well understood. In this paper, computer simulations were performed to investigate the influence of input measurement noise on the accuracy of estimates. The results show that input measurement noise causes considerable variability in the parameter estimates.
利用正电子发射断层扫描（PET）进行示踪剂动力学建模需要测量血浆（PTAC）和组织（TTAC）中的时间-活度曲线，以估计生理参数。然而，这种估计通常忽略了血浆示踪剂活度曲线中的测量噪声。忽略此类噪声所估计的生理参数的准确性和可靠性尚不清楚。本文进行了计算机模拟，以研究输入测量噪声对估计准确性的影响。结果表明，输入测量噪声会导致参数估计出现相当大的变异性。
