Institute for Clinical Chemistry, University Hospital Zurich, Rämistrasse 100, 8091 Zürich, Switzerland.
Anal Bioanal Chem. 2010 Nov;398(6):2573-94. doi: 10.1007/s00216-010-3986-z. Epub 2010 Jul 22.
Liquid chromatography coupled to mass spectrometry nowadays plays an important role in the field of therapeutic drug monitoring (TDM), especially of new compounds for which no immunoassays are available. This paper reviews LC-MS(-MS) methods published recently for anti-infective drugs: antiretroviral drugs, other antiviral drugs, antibacterial drugs, antihelmintic drugs, antimalarial drugs, and other antiprotozoal drugs. An overview of the different methods is given, with special focus on selection of the internal standard and validation procedures.
目前，液相色谱-质谱联用在治疗药物监测（TDM）领域发挥着重要作用，特别是对于那些没有免疫检测方法的新型化合物。本文综述了最近发表的用于抗感染药物的 LC-MS(-MS)方法：抗逆转录病毒药物、其他抗病毒药物、抗菌药物、抗蠕虫药物、抗疟药物和其他抗原生动物药物。本文概述了不同的方法，并特别关注内标物的选择和验证程序。
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