Mori T, Morimoto T, Komaki K, Monden Y
Second Department of Surgery, School of Medicine, University of Tokushima, Japan.
Cancer. 1991 Aug 1;68(3):532-7. doi: 10.1002/1097-0142(19910801)68:3<532::aid-cncr2820680314>3.0.co;2-g.
Estrogen receptors (ER) and epidermal growth factor receptors (EGFR) in the tumor cells of breast cancer tissues (primary tumors) and metastatic lymph nodes (involved nodes) were analyzed by immunocytochemical study in 19 patients; 12 were ER positive, and seven were ER negative. Microscopic study was used to determine the percentage of positive cells and the staining index. The percentage of EGFR-positive cells and the EGFR staining index were higher in the ER-negative primary tumors than ER-positive primary tumors. In ER-positive cases, both the number of ER-positive cells and ER content per cell was less in the involved nodes than in the primary tumors, whereas the number of EGFR-positive cells and EGFR content per cell was greater in affected nodes. On the other hand, in the ER-negative cases the number of EGFR-positive cells and EGFR content per cell remain almost unchanged between the primary tumors and involved nodes. The authors supposed a probability, in this study, that estrogen may exert inhibitory action on EGFR production through binding to ER.
通过免疫细胞化学研究分析了19例乳腺癌组织（原发性肿瘤）和转移性淋巴结（受累淋巴结）肿瘤细胞中的雌激素受体（ER）和表皮生长因子受体（EGFR）；12例ER阳性，7例ER阴性。采用显微镜研究确定阳性细胞百分比和染色指数。ER阴性原发性肿瘤中EGFR阳性细胞百分比和EGFR染色指数高于ER阳性原发性肿瘤。在ER阳性病例中，受累淋巴结中ER阳性细胞数量和每个细胞的ER含量均低于原发性肿瘤，而受累淋巴结中EGFR阳性细胞数量和每个细胞的EGFR含量则更高。另一方面，在ER阴性病例中，原发性肿瘤和受累淋巴结之间EGFR阳性细胞数量和每个细胞的EGFR含量几乎保持不变。作者在本研究中推测，雌激素可能通过与ER结合对EGFR产生发挥抑制作用。
