Yoneda T, Nishimura R, Kato I, Ohmae M, Takita M, Sakuda M
Second Department of Oral and Maxillofacial Surgery, Osaka University Faculty of Dentistry, Japan.
Cancer. 1991 Aug 1;68(3):617-22. doi: 10.1002/1097-0142(19910801)68:3<617::aid-cncr2820680329>3.0.co;2-l.
There have been a number of reports over the last 15 years of patients with cancer who develop both leukocytosis and hypercalcemia, particularly in patients with cancers of the oral cavity. In this study, the authors report the frequency of hypercalcemia and leukocytosis in 225 patients with oral malignancies. Ten patients (4.4%) had hypercalcemia, 11 patients (4.9%) had leukocytosis, and five (2.2%) had both hypercalcemia and leukocytosis. The occurrence of these two distinct paraneoplastic syndromes in the same patients was greater than could have been expected from chance alone (chi-square = 45.8, P less than 0.0001). This study demonstrates that although hypercalcemia and leukocytosis are relatively uncommon in oral cancers, when they do occur they are frequently associated. To the knowledge of the authors, this is the first report in which the frequency of the association hypercalcemia and leukocytosis is studied in detail in large numbers of patients with oral cancer.
在过去15年里，有许多关于癌症患者出现白细胞增多和高钙血症的报告，特别是口腔癌患者。在本研究中，作者报告了225例口腔恶性肿瘤患者中高钙血症和白细胞增多的发生率。10例患者（4.4%）有高钙血症，11例患者（4.9%）有白细胞增多，5例（2.2%）既有高钙血症又有白细胞增多。这两种不同的副肿瘤综合征在同一患者中的出现率高于仅由偶然因素预期的情况（卡方检验=45.8，P<0.0001）。本研究表明，虽然高钙血症和白细胞增多在口腔癌中相对不常见，但当它们出现时往往是相关的。据作者所知，这是首次对大量口腔癌患者中高钙血症和白细胞增多的关联频率进行详细研究的报告。
