Department of Medicine, Weill Cornell Medical Center, New York, New York, USA.
J Hosp Med. 2011 May;6(5):309-11. doi: 10.1002/jhm.676. Epub 2010 Jul 22.
The HIV-associated immune reconstitution inflammatory syndrome usually manifests as new infections or worsening of pre-existing infections during the first few months of initiating anti-retroviral therapy. It is commonly associated with local or systemic inflammation, presumably due to rapid reconstitution of host immune system. Here we describe a unique case of the immune reconstitution inflammatory syndrome presenting as acute pericarditis and pericardial effusion caused by mycobacterium avium complex. We also demonstrate that judicious use of steroids, along with pathogen specific antimicrobial therapy, can prevent local complications of the inflammatory response.
HIV 相关免疫重建炎症综合征通常表现为在开始抗逆转录病毒治疗的最初几个月内新感染或原有感染恶化。它通常与局部或全身炎症有关，可能是由于宿主免疫系统的快速重建。在这里，我们描述了一例独特的免疫重建炎症综合征病例，表现为急性心包炎和由鸟分枝杆菌复合群引起的心包积液。我们还证明，合理使用类固醇，以及针对病原体的特定抗菌治疗，可以预防炎症反应的局部并发症。
