Department of Biochemistry, Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.
Head Neck. 2011 Apr;33(4):482-9. doi: 10.1002/hed.21468.
Aberrant nuclear accumulation of proteins influences tumor development and may predict biologic aggressiveness and disease prognosis. This study determined the prognostic significance of pSTAT3 (phosphorylayed signal transducer and activator of transcription 3) in oral squamous cell carcinomas (OSCCs).
Using immunohistochemistry, a significant increase in nuclear accumulation of pSTAT3 was observed in 49 of 90 leukoplakias (54.4%) and 63/94 OSCCs (67%) (p(trend) < .001). Increased pSTAT3 was associated with tumor stage (p = .01), nodal metastasis (p = .0018), and tobacco consumption (p = .004). Kaplan-Meier analysis demonstrated that OSCC with increased nuclear pSTAT3 showed significantly reduced disease-free survival (13 months), compared with the patients with no nuclear pSTAT3 expression (64 months, p = .019). Cox regression analysis revealed nuclear pSTAT3 as the most significant predictor of poor prognosis (p = .024, hazard ratio [HR] = 2.7).
Increased nuclear accumulation of pSTAT3 occurs in early premalignant stages and is a marker for poor prognosis of OSCC.
蛋白质异常核积累会影响肿瘤的发展，并可能预测生物学侵袭性和疾病预后。本研究旨在确定磷酸化信号转导和转录激活因子 3（pSTAT3）在口腔鳞状细胞癌（OSCC）中的预后意义。
采用免疫组织化学法，在 90 例口腔白斑（leukoplakia）中的 49 例（54.4%）和 94 例 OSCC 中的 63 例（67%）中观察到 pSTAT3 的核内积累显著增加（p<0.001）。pSTAT3 表达增加与肿瘤分期（p=0.01）、淋巴结转移（p=0.0018）和烟草使用（p=0.004）相关。Kaplan-Meier 分析表明，与无核 pSTAT3 表达的患者相比，核内 pSTAT3 表达增加的 OSCC 患者无病生存率显著降低（13 个月 vs. 64 个月，p=0.019）。Cox 回归分析显示核内 pSTAT3 是预后不良的最显著预测因子（p=0.024，风险比[HR]=2.7）。
pSTAT3 的核内积累发生在早期癌前阶段，是 OSCC 预后不良的标志物。
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