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[以方舟为传播媒介的甲型肝炎暴发]

[Hepatitis A outbreak with arca as the vehicle of transmission].

作者信息

Chen H

机构信息

Ningbo Hygiene and Epidemic Prevention Station.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 1991 Apr;12(2):87-90.

PMID:2065348
Abstract

An outbreak of hepatitis A occurred during the period from January 20th to April 30 1988 in Ningbo City. 47,313 patients were reported and four patients died. Morbidity rate was 949.78 per 1,000,000 and fatality rate was 0.08 per 1,000. The positivity rate of anti-HAV IgM in the patient's sera was 95.55%. The history of eating Arca was 82.56% among the patients. Retrospective cohort studies showed that the morbidity of the residents who had eaten Arca was 8.53%, and that of the residents who had not eaten Arca was 0.77%. The difference was highly significant (P less than 0.01, chi 2 = 39.49, RR = 11.08). The attributable risk percent (AR%) of the resident eating Arca was 90.97%. HAV and HAV RNA have been observed in the body of Arca bought from Qidong County, Jiangsu Province, bred in the seashore of Ningbo City for 59 days, by the method of tissue-culture and DNA hybridization assay.

摘要

1988年1月20日至4月30日期间,宁波市发生了甲型肝炎暴发。共报告47313例患者,4例死亡。发病率为每100万人949.78例,病死率为每1000人0.08例。患者血清中抗甲型肝炎病毒IgM阳性率为95.55%。患者中有82.56%有食用毛蚶史。回顾性队列研究表明,食用毛蚶的居民发病率为8.53%,未食用毛蚶的居民发病率为0.77%。差异具有高度显著性(P<0.01,χ2=39.49,RR=11.08)。食用毛蚶居民的归因危险度百分比(AR%)为90.97%。通过组织培养和DNA杂交试验方法,在从江苏省启东县购买、在宁波市海滨养殖59天的毛蚶体内检测到甲型肝炎病毒和甲型肝炎病毒RNA。

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