Mycotoxins are found worldwide in cereal grains, animal feed and human food that are produced from contaminated grains. This presents food safety risks. A variety of methods has been developed to reduce the safety risks by removing mycotoxins from contaminated grain products, eliminate the bioavailability of mycotoxins in the gastrointestinal system, degrade mycotoxins in food and feed, reduce mycotoxins pre- and post-harvest, and prevent (mycotoxin involved) plant disease. These techniques include physical methods such as flotation, extraction and adsorption, chemical reactions such as alkalization, oxidation, heat and irradiation, as well as biological detoxifications using microorganisms, enzymes and resistant plants. Most of the recent patented techniques for detoxification of mycotoxins in feeds and food matrices are discussed for an improved understanding of the patent techniques and insights into detoxification of mycotoxins.