Wu Ting, Sun Qin-feng, Yang Pi-shan, Feng Wei, Liu Xiao-ling
Department of Periodontology, School of Stomatology, Shandong University, Jinan 250012, China.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2010 May;45(5):265-8.
To determine the level of high-density lipoprotein cholesterol (HDL-C), serum C-reactive protein (CRP) and inflammation cytokines and investigate the concentration between periodontal disease and coronary heart disease (CHD).
Sixty-six patients with CHD and chronic periodontitis [(C+P) group], forty-four with only CHD (C group), fifty-six with only chronic periodontitis (C group), and forty-three healthy controls (H group) were included in this study. The diagnosis of chronic periodontitis and CHD was based on accepted clinical criteria. Serum levels of HDL-C, CRP, IL-6, tumor necrosis factor (TNF)-alpha and IL-1beta were tested in all patients and controls.
The periodontal conditions of these four groups were significantly different (P<0.05). The clinical periodontal parameters [probing depth (PD), attachment loss (AL), and bleeding on probing (BOP)] in patients with (C+P) group, P group, C group and H group were [(4.55+/-0.85) mm, (3.78+/-0.34) mm, 69.6%], [(4.06+/-0.61) mm, (3.05+/-0.44) mm, 63.6%], [(1.85+/-0.67) mm, (1.26+/-0.39) mm, 20.5%], [(1.12+/-0.33) mm, (0.42+/-0.83) mm, 4.6%], respectively. The levels of HDL-C in H group, C group, P group and (C+P) group were (1.42+/-0.21), (1.22+/-0.18), (1.24+/-0.21) and (1.04+/-0.22) mmol/L, respectively. T compare with other three groups, the level of HDL-C in (C+P) group is the lowest. The levels of CRP, IL-6, TNF-alpha and IL-1beta in (C+P) group were significantly higher than other groups (P<0.05).
HDL-C, CRP, IL-6, TNF-alpha and IL-1beta may be associated with the pathogenesis of periodontitis and CHD. There may be a relationship between the two diseases.
测定高密度脂蛋白胆固醇（HDL-C）、血清C反应蛋白（CRP）及炎症细胞因子水平，探讨牙周病与冠心病（CHD）之间的浓度关系。
本研究纳入66例冠心病合并慢性牙周炎患者[（C+P）组]、44例仅患有冠心病患者（C组）、56例仅患有慢性牙周炎患者（P组）以及43例健康对照者（H组）。慢性牙周炎和冠心病的诊断依据公认的临床标准。检测所有患者及对照者血清中HDL-C、CRP、白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）-α和白细胞介素-1β（IL-1β）的水平。
这四组的牙周状况存在显著差异（P<0.05）。（C+P）组、P组、C组和H组患者的临床牙周参数[探诊深度（PD）、附着丧失（AL）和探诊出血（BOP）]分别为[（4.55±0.85）mm，（3.78±0.34）mm，69.6%]、[（4.06±0.61）mm，（3.05±0.44）mm，63.6%]、[（1.85±0.67）mm，（1.26±0.39）mm，20.5%]、[（1.12±0.33）mm，（0.42±0.83）mm，4.6%]。H组、C组、P组和（C+P）组的HDL-C水平分别为（1.42±0.21）、（1.22±0.18）、（1.24±0.21）和（1.04±0.22）mmol/L。与其他三组相比，（C+P）组的HDL-C水平最低。（C+P）组的CRP、IL-6、TNF-α和IL-1β水平显著高于其他组（P<0.05）。
HDL-C、CRP、IL-6、TNF-α和IL-1β可能与牙周炎和冠心病的发病机制有关。这两种疾病之间可能存在关联。
