内皮素-1对清醒正常血压家兔动脉血压和心肌收缩力的影响。

Effects of endothelin-1 on arterial pressure and myocardial contractility in the conscious normotensive rabbit.

Roberts-Thomson P, McRitchie R J, Chalmers J P

Department of Medicine, Flinders Medical Centre, Bedford Park, South Australia.

Clin Exp Pharmacol Physiol. 1991 May;18(5):315-8. doi: 10.1111/j.1440-1681.1991.tb01453.x.

Abstract

We studied the effects of an intravenous bolus of endothelin-1 on arterial pressure and myocardial contractility in the conscious rabbit. 2. Endothelin produced an initial fall in arterial pressure accompanied by an increase in heart rate. This was followed by a dose-dependent increase in arterial pressure, peaking about 7 min after injection, accompanied by a reciprocal fall in heart rate. 3. Left ventricular rate of change of pressure (LV dP dt) increased with endothelin except at higher doses (0.8 and 1.6 nmol/kg), where in some animals it decreased.

摘要

我们研究了静脉注射大剂量内皮素-1对清醒家兔动脉血压和心肌收缩力的影响。2. 内皮素导致动脉血压起初下降，并伴有心率增加。随后动脉血压呈剂量依赖性升高，在注射后约7分钟达到峰值，同时心率相应下降。3. 除了较高剂量（0.8和1.6 nmol/kg）外，内皮素使左心室压力变化率（LV dP dt）增加，在某些动物中，较高剂量时该指标会下降。