自发性高血压大鼠血管平滑肌的多种生长异常

Multiple growth abnormalities in vascular smooth muscle from spontaneously hypertensive rats.

Saltis J, Little P, Bobik A

Baker Medical Research Institute, Alfred Hospital, Prahran, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1991 May;18(5):319-22. doi: 10.1111/j.1440-1681.1991.tb01454.x.

Abstract

In tissue culture the growth characteristics of aortic smooth muscle cells isolated from spontaneously hypertensive rats (SHR) were compared with those of normotensive Wistar-Kyoto (WKY) rats. 2. Aortic smooth muscle cells from SHR exhibit enhanced proliferation when grown in the presence of low (1%) and moderate (5%) concentrations of fetal calf serum. 3. Cell quiescence in cultures of smooth muscle from SHR becomes apparent at cell densities approximately 20% higher than in cultures from WKY rats. 4. These different growth characteristics of smooth muscle between the two strains of rats may contribute to the early pre-hypertensive development of vascular hypertrophy in the SHR.

摘要

在组织培养中，比较了从自发性高血压大鼠（SHR）分离的主动脉平滑肌细胞与正常血压的Wistar-Kyoto（WKY）大鼠的主动脉平滑肌细胞的生长特性。2. 当在低（1%）和中等（5%）浓度的胎牛血清存在下生长时，SHR的主动脉平滑肌细胞表现出增强的增殖。3. SHR平滑肌培养物中的细胞静止在细胞密度比WKY大鼠培养物中高约20%时变得明显。4. 两种大鼠品系之间平滑肌的这些不同生长特性可能有助于SHR中血管肥大的高血压前期早期发展。