营养保健品抑制肌肉蛋白水解：二烯丙基硫化物在治疗肌肉萎缩中的作用。
Nutraceutical inhibition of muscle proteolysis: a role of diallyl sulphide in the treatment of muscle wasting.
机构信息
Cancer Research Group, Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, Barcelona 08028, Spain.
出版信息
Clin Nutr. 2011 Feb;30(1):33-7. doi: 10.1016/j.clnu.2010.06.004. Epub 2010 Jul 22.
BACKGROUND & AIMS: The abnormalities associated with cancer cachexia include anorexia, weight loss, muscle loss and atrophy, anaemia and alterations in carbohydrate, lipid and protein metabolism. The aim of the present investigation was to examine the anti-wasting effects of some nutraceuticals such as genistein, resveratrol, epigallocatechin gallate and diallyl sulphide (DAS).
METHODS
The in vitro effects of these nutraceuticals on proteolysis were examined in muscle cell cultures submitted to hyperthermia. The in vivo effects of DAS were also tested in cachectic tumour-bearing rats (Yoshida AH-130 ascites hepatoma).
RESULTS
Although all the nutraceuticals tested inhibited muscle proteolysis, the most promising effects were related with DAS. In vivo administration of DAS only leads to a small improvement in tibialis muscle and heart weights; however, administration of DAS to healthy animals increased all muscle weights, this being associated with a decreased gene expression of proteolytic systems components.
CONCLUSION
It may be suggested that DAS could be used to improve muscle mass during healthy conditions.
背景与目的
癌症恶病质相关的异常包括厌食、体重减轻、肌肉损失和萎缩、贫血以及碳水化合物、脂质和蛋白质代谢的改变。本研究旨在研究一些营养保健品（如染料木黄酮、白藜芦醇、表没食子儿茶素没食子酸酯和二烯丙基二硫（DAS））的抗消瘦作用。
方法
在接受高温处理的肌肉细胞培养物中，检查这些营养保健品对蛋白水解的体外作用。还在患有恶病质的荷瘤大鼠（Yoshida AH-130 腹水肝癌）中测试 DAS 的体内作用。
结果
尽管所有测试的营养保健品都抑制肌肉蛋白水解，但最有希望的作用与 DAS 有关。DAS 的体内给药仅导致胫骨和心脏重量略有改善；然而，DAS 给药给健康动物增加了所有肌肉的重量，这与降低蛋白水解系统成分的基因表达有关。
结论
可以认为 DAS 可用于在健康条件下改善肌肉质量。
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