Cancer Research Group, Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028-Barcelona, Spain.
Clin Nutr. 2013 Jun;32(3):319-24. doi: 10.1016/j.clnu.2013.01.004. Epub 2013 Jan 22.
Cachexia is a multiorganic syndrome associated with cancer, characterized by body weight loss, muscle and adipose tissue wasting and inflammation, being often associated with anorexia. The aim of the present review is to examine the impact of megestrol acetate in the treatment of cancer cachexia, both at the biochemical and physiological level taking into account new experimental data related to protein muscle metabolism. Based on experimental evidence, it is concluded that megestrol acetate is a good candidate for muscle wasting treatment and future studies addressed at the interaction between the drug and protein turnover in human skeletal muscle should be performed.
恶病质是一种与癌症相关的多器官综合征，其特征是体重下降、肌肉和脂肪组织消耗以及炎症，常伴有厌食。本综述的目的是检查醋酸甲地孕酮在治疗癌症恶病质中的作用，从生化和生理水平考虑与肌肉蛋白代谢相关的新实验数据。基于实验证据，结论认为醋酸甲地孕酮是治疗肌肉消耗的一个很好的候选药物，应该进行针对该药物与人类骨骼肌蛋白周转率之间相互作用的进一步研究。
