缓解首发精神病患者的生活质量。
Quality of life in patients who have remitted from their first episode of psychosis.
机构信息
Orygen Youth Health Research Centre, Centre for Youth Mental Health, The University of Melbourne, Australia.
出版信息
Schizophr Res. 2010 Aug;121(1-3):259-65. doi: 10.1016/j.schres.2010.05.027. Epub 2010 Jun 18.
BACKGROUND
Quality of life (QoL) in first-episode psychosis (FEP) is strongly related to levels of psychopathology and may vary as a function of illness phase. QoL remains poorly understood in FEP.
AIM
Characterise the nature and predictors of QoL in patients who have remitted from their first-episode of psychosis.
METHOD
Demographic characteristics, diagnoses, and psychopathology were assessed in 81 FEP patients. The World Health Organization Quality of Life Scale-Bref (WHOQoL-Bref) was used to assess QoL in these patients. Carer-related variables (expressed emotion and burden of care) were ascertained from 63 relatives.
RESULTS
Poorer QoL was associated with personality disorder, depression, mild psychotic positive symptoms, and impaired functioning. Carer-related factors such as emotional overinvolvement and burden of care were also associated with a reduction in patients' QoL.
CONCLUSIONS
Depression, functioning and family variables impacted on QoL, and need to be considered in terms of ongoing patient management.
背景
首发精神病（FEP）患者的生活质量（QoL）与其精神病理学水平密切相关，并且可能会随着疾病阶段的变化而变化。然而，在 FEP 患者中，其 QoL 仍然知之甚少。
目的
描述已从首次精神病发作中缓解的患者的 QoL 的性质和预测因素。
方法
评估了 81 例 FEP 患者的人口统计学特征、诊断和精神病理学。使用世界卫生组织生活质量量表简表（WHOQoL-Bref）评估这些患者的 QoL。从 63 位亲属那里确定了与照顾者相关的变量（表达的情绪和照顾负担）。
结果
较差的 QoL 与人格障碍、抑郁、轻度阳性精神病症状和功能障碍有关。照顾者相关的因素，如情绪过度卷入和照顾负担，也与患者 QoL 的降低有关。
结论
抑郁、功能和家庭变量对 QoL 有影响，在考虑患者的管理时需要考虑这些因素。
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