Chen D X, Zheng D S, Zhang S H, Wu Y X, Bao S H, Xia L L
Renji Hospital, Shanghai Second Medical University.
Chin Med J (Engl). 1991 Apr;104(4):330-5.
The ablative effect of argon laser delivered fibreoptically in vitro on 234 segments of atherosclerotic human aorta was studied. The variables such as energy density, type of atheroma and immersion media were included, and all irradiated specimens were subsequently submitted to histological examination and crater volumes in mm3 to micrometer measurements under light microscope. The results showed 1) a linear relationship between energy dose and crater volume in fibrous atheroma, 2) significantly greater damage or surrounding in the higher energy dose groups, 3) a lower dose response in calcified tissue than in fatty streaks or fibrous atheroma, and 4) immersion of tissue in blood during ablation resulted in a significantly greater dose response than immersion in plasma or saline, and the corresponding surrounding tissue damage was greatest when immersed in blood. Thus, argon laser is both effective and predictable in response during ablating of atheromatous tissue. The efficacy of the process is dependent on immersion medium, while the degree of surrounding tissue damage is dependent on energy dose.
研究了通过光纤传输的氩激光在体外对234段人类动脉粥样硬化主动脉的消融作用。研究变量包括能量密度、动脉粥样硬化类型和浸泡介质，所有照射后的标本随后都进行了组织学检查，并在光学显微镜下测量了以立方毫米至微米为单位的弹坑体积。结果显示：1）纤维性动脉粥样硬化中能量剂量与弹坑体积之间呈线性关系；2）高能量剂量组的损伤或周围组织损伤明显更大；3）钙化组织中的剂量反应低于脂肪条纹或纤维性动脉粥样硬化；4）消融过程中组织浸泡在血液中时的剂量反应明显大于浸泡在血浆或盐水中，且浸泡在血液中时相应的周围组织损伤最大。因此，氩激光在消融动脉粥样硬化组织时的反应既有效又可预测。该过程的疗效取决于浸泡介质，而周围组织损伤程度取决于能量剂量。
