Max-Planck-Institute for Dynamics of Complex Technical Systems, Systems Biology Group, Sandtorstr. 1, Magdeburg, Germany.
Biophys J. 2010 Jul 7;99(1):L4-6. doi: 10.1016/j.bpj.2010.04.018.
We report on the first observation of inward rotating spiral waves (antispirals) in a biochemical reaction-diffusion system. Experiments are performed with extracts from yeast cells in an open spatial reactor. By increasing the protein concentration of the extract we observe a transition from outward to inward propagating waves of glycolytic activity. Numerical simulations with an allosteric model for the phosphofructokinase can reproduce these inward propagating waves over a wide range of parameters if the octameric structure of yeast phosphofructokinase is taken into account.
我们报告了在生化反应-扩散系统中首次观察到的内旋螺旋波（反旋）。实验是在开放空间反应器中的酵母细胞提取物中进行的。通过增加提取物中的蛋白质浓度，我们观察到从外向内传播的糖酵解活性波的转变。如果考虑到酵母磷酸果糖激酶的八聚体结构，用变构模型进行的数值模拟可以在广泛的参数范围内再现这些向内传播的波。
