National Center for Environmental Assessment, U.S. Environmental Protection Agency, 109 TW Alexander Drive, Mailcode B-243-01, Research Triangle Park, NC 27711, USA.
Clin Biochem. 2010 Oct;43(15):1183-8. doi: 10.1016/j.clinbiochem.2010.07.011. Epub 2010 Jul 23.
Carbon monoxide (CO) in tissues and cells can originate from inhalation of CO or endogenously. Endogenous production, carboxyhemoglobin (COHb) formation, and exhaled CO levels are influenced by physiological factors, including disease. It is suggested that endogenous CO production can be used as a biomarker for oxidative and inflammatory processes. Also, endogenous CO can contribute to increased body burden of CO, which may both disrupt normal CO signaling cascades and increase the risk of CO toxicity.
组织和细胞中的一氧化碳（CO）可能来自于吸入 CO 或内源性产生。内源性产生、碳氧血红蛋白（COHb）形成和呼出的 CO 水平受生理因素的影响，包括疾病。有人认为，内源性 CO 产生可以作为氧化和炎症过程的生物标志物。此外，内源性 CO 可以导致 CO 的体内负荷增加，这可能会破坏正常的 CO 信号级联反应并增加 CO 毒性的风险。
