自身免疫性疾病中 baff 的最新消息。
The late news on baff in autoimmune diseases.
机构信息
Department of "Immunology and Pathology", European University of Brest, France.
出版信息
Autoimmun Rev. 2010 Oct;9(12):804-6. doi: 10.1016/j.autrev.2010.06.011. Epub 2010 Jul 23.
The B cell-activating factor of the tumor-necrosis factor family (BAFF) plays a dominant role in the B cell homeostasis. By rescuing autoreactive B cells, excessive BAFF favors the development of autoimmune diseases. Given the numbers of variants of this B cell-specific cytokine, caution must be exercized when determining its serum level. Alternate splice isoforms, such as Δ3 BAFF and Δ4 BAFF, have been identified. They raise the possibility that their overproduction impact the synthesis of full-length BAFF.
肿瘤坏死因子家族的 B 细胞激活因子（BAFF）在 B 细胞的体内平衡中起着主导作用。通过挽救自身反应性 B 细胞，过量的 BAFF 有利于自身免疫性疾病的发展。鉴于这种 B 细胞特异性细胞因子的变体数量众多，在确定其血清水平时必须谨慎。已经鉴定出其他剪接异构体，如 Δ3 BAFF 和 Δ4 BAFF。它们提出了这样一种可能性，即它们的过度产生会影响全长 BAFF 的合成。
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