BAFF在自身免疫中对辅助性T细胞的作用。
The function of BAFF on T helper cells in autoimmunity.
作者信息
Chen Maogen, Lin Xiaohong, Liu Ya, Li Qiang, Deng Yiling, Liu Zhongmin, Brand David, Guo Zhiyong, He Xiaoshun, Ryffel Bernhard, Zheng Song Guo
机构信息
Organ Transplant Center, 1st Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, PR China; Division of Rheumatology and Immunology, Department of Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA.
Division of Rheumatology and Immunology, Department of Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA; Department of Thyroid and Breast Surgery, Huangpu Branch of the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510700, PR China.
出版信息
Cytokine Growth Factor Rev. 2014 Jun;25(3):301-5. doi: 10.1016/j.cytogfr.2013.12.011. Epub 2013 Dec 24.
Abstract
B cell-activating factor belonging to the TNF family (BAFF) exerts its pathogenic role in supporting the survival and proliferation of B cells, regulating class switch recombination as well as the selection of autoreactive B cells. Overexpression of BAFF induces a dramatic expansion of activated B cells, particularly marginal zone B cells, as well as hypergammaglobulinemia, autoantibody production and immune complex deposition. However, in addition to its effect on B cells, recent work has also demonstrated that BAFF can promote T cell activation, proliferation and differentiation. In this review, we have discussed the recent progress on the function and role of BAFF on T cells and T cell-mediated diseases.
摘要
肿瘤坏死因子家族成员B细胞活化因子（BAFF）在支持B细胞存活和增殖、调节类别转换重组以及自身反应性B细胞选择方面发挥致病作用。BAFF的过表达会导致活化B细胞显著扩增，尤其是边缘区B细胞，同时还会引起高球蛋白血症、自身抗体产生和免疫复合物沉积。然而，除了对B细胞的作用外，最近的研究还表明BAFF可促进T细胞活化、增殖和分化。在本综述中，我们讨论了BAFF在T细胞及T细胞介导的疾病中的功能和作用的最新进展。
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