Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
J Am Soc Echocardiogr. 2010 Sep;23(9):938-42. doi: 10.1016/j.echo.2010.06.018. Epub 2010 Jul 24.
Coronary artery wall echogenicity increases on echocardiograms during the acute phase of Kawasaki disease (KD). According to this background, echogenicity of the coronary artery wall in patients with KD is quantified by using integrated backscatter (IB) analysis.
IB analysis is a quantitative method for evaluating echogenicity. We examined the value of IB in the wall of the left anterior descending coronary artery and compared it with that in adjacent intracardiac blood as a measure of background. The difference between these values is represented as corrected IB for the coronary artery wall.
Corrected IB for the coronary artery wall was higher in patients with KD than in controls (KD with pre-immunoglobulin therapy vs. controls: 27.4 +/- 5.3 dB vs. 22.0 +/- 3.5 dB, P < .05) and in patients with coronary enlargement after intravenous immunoglobulin (with vs. without coronary enlargement, 29.2 +/- 5.2 dB vs. 24.1 +/- 5.5 dB, P < .05).
The magnitude of IB from the coronary artery wall reflects the effectiveness of immunoglobulin therapy. Furthermore, this method and its value might be useful to predict the occurrence of coronary enlargement in patients with KD.
川崎病（KD）急性期的超声心动图检查可见冠状动脉壁回声增强。基于这一背景，本研究采用背向散射积分（IB）分析对 KD 患者冠状动脉壁回声强度进行定量评估。
IB 分析是一种评估回声强度的定量方法。我们检测了左前降支冠状动脉壁的 IB 值，并将其与相邻心内血液的 IB 值进行比较，以作为背景的测量值。两者的差值即为冠状动脉壁校正 IB（corrected IB for the coronary artery wall，cIB）。
KD 患者的 cIB 高于对照组（接受免疫球蛋白治疗前的 KD 患者 vs. 对照组：27.4±5.3 dB vs. 22.0±3.5 dB，P＜0.05），且冠状动脉扩张的 KD 患者的 cIB 高于无冠状动脉扩张的患者（有 vs. 无冠状动脉扩张，29.2±5.2 dB vs. 24.1±5.5 dB，P＜0.05）。
冠状动脉壁 IB 值的大小反映了免疫球蛋白治疗的效果。此外，该方法及其价值可能有助于预测 KD 患者发生冠状动脉扩张的可能性。
