Department of Endocrinology, Diabetology and Metabolic Diseases, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium.
J Diabetes Complications. 2011 Mar-Apr;25(2):137-41. doi: 10.1016/j.jdiacomp.2010.05.003. Epub 2010 Jul 24.
Cystic fibrosis (CF) is one of the most common genetically inherited diseases and often complicated by diabetes mellitus. With increasing longevity, the incidence and prevalence of cystic fibrosis-related diabetes (CFRD) rise and microvascular complications develop. CFRD is an entity on its own with characteristics seen in both type 1 and type 2 diabetes. Keto-acidosis, a potentially life-threatening complication of diabetes, is an extremely rare presentation of CFRD. Here we present the history of a 21-year-old CF patient with no prior diagnosis of CFRD who developed keto-acidosis after an episode of pulmonary infection. Based on this case report we would like to emphasize the importance of screening for and early treatment of CFRD. We also discuss the management policy of CFRD and when and whether to initiate insulin therapy.
囊性纤维化（CF）是最常见的遗传性疾病之一，常并发糖尿病。随着寿命的延长，囊性纤维化相关性糖尿病（CFRD）的发病率和患病率上升，微血管并发症也随之发展。CFRD 是一种独立的疾病实体，具有 1 型和 2 型糖尿病的特征。酮症酸中毒是糖尿病一种潜在危及生命的并发症，在 CFRD 中极为罕见。本文报告了一例 21 岁 CF 患者，既往无 CFRD 诊断，在一次肺部感染后发生酮症酸中毒。基于该病例报告，我们强调筛查和早期治疗 CFRD 的重要性。我们还讨论了 CFRD 的管理策略，以及何时以及是否启动胰岛素治疗。
