Institute for Ageing and Health, Newcastle University, Newcastle-upon-Tyne, UK.
Arch Dis Child. 2011 Sep;96(9):863-9. doi: 10.1136/adc.2009.165712. Epub 2010 Jul 23.
Epigenetic mechanisms are believed to play an important role in disease, development and ageing with early life representing a window of particular epigenomic plasticity. The knowledge upon which these claims are based is beginning to expand. This review summarises evidence pointing to the determinants of epigenetic patterns, their juxtaposition at the interface of the environment, their influence on gene function and the relevance of this information to child health.
表观遗传机制被认为在疾病、发育和衰老中起着重要作用，而生命早期代表着特别具有表观基因组可塑性的一个窗口。这些主张所依据的知识正在开始扩展。这篇综述总结了指向表观遗传模式决定因素的证据，它们在环境界面上的并置，它们对基因功能的影响，以及这些信息对儿童健康的相关性。
