Gosling P, Hughes E A, Reynolds T M, Fox J P
Department of Biochemistry, Selly Oak Hospital, Birmingham, U.K.
Eur Heart J. 1991 Apr;12(4):508-13. doi: 10.1093/oxfordjournals.eurheartj.a059931.
Ninety-six patients admitted to two coronary care units with suspected acute myocardial infarction were studied. The diagnosis was confirmed in 44, the remaining 52 were used as a control group. The first urine passed after admission, together with early morning urines on the following 3 days, were saved in all patients. Urinary albumin and IgG were measured by automated immunoturbidimetry and expressed as the protein creatinine ratio in mg.mmol-1. The log mean (SD) albumin creatinine ratios for the first urine passed in the myocardial infarction and non-myocardial infarction patient groups were 6.2(4.2) and 1.3(3.4) respectively. The difference in log mean albumin creatinine ratio was 4.9 mg.mmol-1, 95% CI 3.4 to 6.2 mg.mmol-1; t = 6.127 df = 94, P less than 0.0001. The median IgG creatinine ratio for the first urine passed after admission in myocardial infarction patients was 1.0 mg.mmol-1 (95% CI 0.5 to 1.2) and for non-myocardial infarction patients 0.3 (95% CI 0.2 to 0.4). Increased urinary protein excretion appears to be an early and proportional response to acute myocardial infarction.
对收治于两个冠心病监护病房、疑似急性心肌梗死的96例患者进行了研究。44例确诊，其余52例作为对照组。所有患者均留存入院后首次排尿以及随后3天的晨尿。采用自动免疫比浊法测定尿白蛋白和IgG，并以mg.mmol-1的蛋白肌酐比值表示。心肌梗死患者组和非心肌梗死患者组首次排尿的对数平均（标准差）白蛋白肌酐比值分别为6.2(4.2)和1.3(3.4)。对数平均白蛋白肌酐比值的差异为4.9 mg.mmol-1，95%可信区间为3.4至6.2 mg.mmol-1；t = 6.127，自由度 = 94，P < 0.0001。心肌梗死患者入院后首次排尿的IgG肌酐比值中位数为1.0 mg.mmol-1（95%可信区间为0.5至1.2），非心肌梗死患者为0.3（95%可信区间为0.2至0.4）。尿蛋白排泄增加似乎是对急性心肌梗死的早期且成比例的反应。
