尼卡地平在体内和体外对氧合血红蛋白所致犬基底动脉痉挛的预防作用。

Prevention by nicardipine of dog basilar artery spasm caused by oxyhemoglobin in vivo and in vitro.

作者信息

Toda N, Kawakami M, Kodama N

机构信息

Department of Pharmacology, Shiga University of Medical Sciences, Ohtsu, Japan.

出版信息

Eur J Pharmacol. 1991 Mar 19;195(1):175-7. doi: 10.1016/0014-2999(91)90398-a.

DOI:10.1016/0014-2999(91)90398-a

PMID:2065711

Abstract

Intravenous infusions of nicardipine in a dose insufficient to lower blood pressure prevented the generation of the basilar artery spasm provoked by oxyhemoglobin (oxyHb) injected intracisternally in anesthetized dogs. The plasma concentration of nicardipine was comparable to that sufficient to suppress the oxyHb-induced contraction in isolated dog basilar arteries. Nicardipine appears to be similarly effective in antagonizing the vasoconstrictor action of oxyHb in vivo and in vitro.

摘要

静脉输注剂量不足以降低血压的尼卡地平，可预防麻醉犬脑池内注射氧合血红蛋白（oxyHb）诱发的基底动脉痉挛。尼卡地平的血浆浓度与足以抑制离体犬基底动脉中氧合血红蛋白诱导的收缩的浓度相当。尼卡地平在体内和体外拮抗氧合血红蛋白的血管收缩作用方面似乎同样有效。