Harrogate District Hospital, Harrogate, Yorkshire, UK.
Curr Opin Urol. 2010 Sep;20(5):426-31. doi: 10.1097/MOU.0b013e32833cadb0.
Bladder-sparing bladder treatments have recently been rejuvenated with the introduction of concomitant chemotherapy usually as part of multimodality therapy including endoscopic resection and radiotherapy. This article reviews recent evidence for the role of radiotherapy in the treatment of localized bladder cancer.
Several single institution series of multimodality radiochemotherapy have shown consistently fair disease-specific survival and local control in those who show a complete response after endoscopic resection. Developments in radiotherapy fractionation, adaptive planning and chemotherapy delivery are clearly in progress.
Much of the evidence is retrospective and involves treating locally advanced poor-risk patients. It would seem right to attempt to prospectively evaluate these treatments for truly localized (T1/2) bladder cancer.
随着内镜切除和放疗等多模态治疗中联合化疗的应用，最近对保留膀胱的膀胱治疗方法进行了更新。本文回顾了放疗在局部膀胱癌治疗中的作用的最新证据。
几项多机构的内镜切除后完全缓解患者的多模态放化疗系列研究显示，疾病特异性生存率和局部控制率一致良好。放疗分割、自适应计划和化疗方案的改进显然正在进行中。
大部分证据是回顾性的，涉及治疗局部晚期高危患者。似乎应该尝试前瞻性评估这些治疗方法在真正局限性（T1/2）膀胱癌中的效果。
