工人接触 1-溴丙烷导致剂量依赖性神经异常。
Dose-dependent neurologic abnormalities in workers exposed to 1-bromopropane.
机构信息
School of Public Health/MOE Key Lab for Public Health Safety, Fudan University, Shanghai, China.
出版信息
J Occup Environ Med. 2010 Aug;52(8):769-77. doi: 10.1097/JOM.0b013e3181eaded7.
OBJECTIVES
To investigate the health effects of 1-bromopropane (1-BP) and its dose-dependency in 1-BP production factories in China.
METHODS
Data of 60 female and 26 male workers in three 1-BP factories and the same number of age-, sex-, and region-matched controls were interviewed and examined. The time-weighed average exposure levels of individual workers were estimated.
RESULTS
Regression analysis on exposure level showed dose-dependent increase in the distal latency of tibial nerve, threshold for vibration sense in toes, lactate dehydrogenase, thyroid stimulating hormone, and follicle stimulating hormone in female workers. The analysis also showed dose-dependent decrease in sensory nerve conduction velocity of the sural nerve, red blood cell, and hematocrit in female workers.
CONCLUSIONS
The results indicate that exposure to 1-BP induces dose-dependent neurotoxicity in female workers.
目的
研究中国 1-溴丙烷（1-BP）生产工厂中 1-BP 的健康影响及其剂量依赖性。
方法
对三家 1-BP 工厂的 60 名女性和 26 名男性工人以及相同数量的年龄、性别和地区匹配的对照组进行了访谈和检查。个体工人的时间加权平均暴露水平进行了估计。
结果
暴露水平的回归分析显示，女性工人的远端潜伏期、脚趾振动感阈值、乳酸脱氢酶、促甲状腺激素和卵泡刺激素呈剂量依赖性增加。分析还显示，女性工人的腓肠神经感觉神经传导速度、红细胞和红细胞压积呈剂量依赖性降低。
结论
结果表明，接触 1-BP 会导致女性工人产生剂量依赖性的神经毒性。
Zotero 插件