一些新型噻吩并[2,3-d]嘧啶的合成、表征及生物学研究。
Synthesis, characterization and biological studies of some novel thieno[2,3-d]pyrimidines.
机构信息
Chemistry Department, College of Science, King Faisal University, P.O. Box 400, Hofuf 31982, Saudi Arabia.
出版信息
Molecules. 2010 Jun 1;15(6):3932-57. doi: 10.3390/molecules15063932.
Several 2-unsubstituted thieno[2,3-d]pyrimidines have been prepared from 2-aminothiophene-3-carboxylic acid esters and their carbonitrile analogs. Some triazolo-thienopyrimidine and 2-thioxothienopyrimidine representatives have also been synthesized using thermal and microwave (MW) irradiation techniques. Structures of the prepared compounds were elucidated on the basis of IR, NMR, 2D NMR and mass spectral data. The biological activity of some selected synthesized compounds was also examined.
几种 2-未取代的噻吩并[2,3-d]嘧啶已由 2-氨基噻吩-3-羧酸酯及其腈类似物制备得到。还使用热和微波（MW）辐照技术合成了一些三唑并噻吩嘧啶和 2-硫代噻吩嘧啶代表物。根据红外、核磁共振、二维核磁共振和质谱数据确定了所制备化合物的结构。还检查了一些选定合成化合物的生物活性。
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