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柚皮素与羟丙基-β-环糊精包合物的制备及理化性质。

Preparation and physicochemical properties of the complex of naringenin with hydroxypropyl-beta-cyclodextrin.

机构信息

College of Grain and Food, Henan University of Technology, Zhengzhou 450052, China.

出版信息

Molecules. 2010 Jun 18;15(6):4401-7. doi: 10.3390/molecules15064401.

DOI:10.3390/molecules15064401
PMID:20657449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6264575/
Abstract

In this study a complex of naringenin with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was prepared to improve the hydrophilicity of naringenin. The physicochemical properties of the complex were analyzed by ultraviolet-visible spectrometry (UV), infrared spectrometry (IR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC). The result showed that naringenin had been molecularly dispersed in the HP-beta-CD matrix, not forming a new compound and HPLC analysis showed that the solubility of naringenin in water was enhanced from 4.38 microg/mL to 1,272.31 microg/mL.

摘要

在这项研究中，柚皮素与羟丙基-β-环糊精（HP-β-CD）形成了复合物，以提高柚皮素的亲水性。通过紫外可见光谱（UV）、红外光谱（IR）、X 射线衍射（XRD）、差示扫描量热法（DSC）分析了复合物的理化性质。结果表明，柚皮素已在 HP-β-CD 基质中实现分子分散，未形成新的化合物，且高效液相色谱（HPLC）分析表明，柚皮素在水中的溶解度从 4.38μg/mL 提高到 1272.31μg/mL。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0074/6264575/870c51070517/molecules-15-04401-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0074/6264575/f9819613705c/molecules-15-04401-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0074/6264575/e7d3fe0ae3f4/molecules-15-04401-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0074/6264575/31ba9cd80fc7/molecules-15-04401-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0074/6264575/4ca367eb8250/molecules-15-04401-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0074/6264575/870c51070517/molecules-15-04401-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0074/6264575/f9819613705c/molecules-15-04401-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0074/6264575/e7d3fe0ae3f4/molecules-15-04401-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0074/6264575/31ba9cd80fc7/molecules-15-04401-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0074/6264575/4ca367eb8250/molecules-15-04401-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0074/6264575/870c51070517/molecules-15-04401-g005.jpg

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