Xu Risheng, Sciubba Daniel M, Gokaslan Ziya L, Bydon Ali
Medical Scientist Training Program, Johns Hopkins School of Medicine, Baltimore, Maryland.
Surg Neurol Int. 2010 May 31;1:16. doi: 10.4103/2152-7806.63911.
The management of metastatic spinal disease is generally considered palliative, as the progression of systemic disease is likely to hinder survival. Although the occurrence of C1-C2 instability due to metastatic disease is not uncommon and thus treatment options have been well-defined, craniocervical instability due to lesions occurring at the junction of the occiput and atlas is more rare, and treatment for metastasis to this region is less well-defined.
We present a patient with non-small-cell lung cancer metastatic to the atlanto-occipital facet joint complex. A drastic improvement in the presenting debilitating mechanical neck pain was noted following an occipitocervical fusion. A literature review of published cases of metastases to the occipitocervical junction was conducted along with treatment options.
The atlanto-occipital facet joint is a rare site of metastatic disease. Destruction of this joint can lead to significant neck pain secondary to instability. Spinal fusion may afford significant and rapid resolution of these symptoms, and should be considered in the management of patients-even those with end-stage oncologic disease.
转移性脊柱疾病的治疗通常被认为是姑息性的,因为全身性疾病的进展可能会影响生存。尽管转移性疾病导致C1-C2不稳定的情况并不少见,因此治疗选择已经明确,但枕骨和寰椎交界处病变导致的颅颈不稳定更为罕见,针对该区域转移的治疗方法尚不明确。
我们报告一名非小细胞肺癌转移至寰枕关节复合体的患者。枕颈融合术后,患者出现的使人衰弱的机械性颈部疼痛得到了显著改善。我们对已发表的枕颈交界处转移病例及治疗选择进行了文献综述。
寰枕关节是转移性疾病的罕见部位。该关节的破坏可导致继发于不稳定的严重颈部疼痛。脊柱融合术可显著且迅速地缓解这些症状,在患者的治疗中应予以考虑,即使是那些患有终末期肿瘤疾病的患者。