鸟类外分泌胰腺的尿酸合成
Uric acid synthesis by avian exocrine pancreas.
作者信息
Herzberg G R, Coady K, Maddigan B, MacCharles G
机构信息
Biochemistry Department, Memorial University of Newfoundland, St John's, Canada.
出版信息
Int J Biochem. 1991;23(5-6):545-8. doi: 10.1016/0020-711x(87)90048-6.
PMID:2065817
Abstract
- Chicken pancreas has been shown to synthesize and secrete uric acid. Uric acid synthesis from xanthine in vitro by isolated pancreatic acinii is saturable and dependent on the activity of xanthine dehydrogenase. 2. Chicken pancreas is unable to synthesize uric acid de novo but the variety of substrates which support urate synthesis suggests that it occurs by the purine degradation pathway.
摘要
- 已证实鸡胰腺能合成并分泌尿酸。离体胰腺腺泡在体外由黄嘌呤合成尿酸的过程是可饱和的，且依赖于黄嘌呤脱氢酶的活性。2. 鸡胰腺无法从头合成尿酸，但支持尿酸合成的多种底物表明其是通过嘌呤降解途径发生的。
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