Department of Ophthalmology, Semmelweis University, Budapest, Hungary.
Arch Dermatol Res. 2010 Nov;302(9):695-700. doi: 10.1007/s00403-010-1067-y. Epub 2010 Jul 24.
A case of basal cell carcinoma (BCC) with intratumoural bone formation affecting the eyelid of a 77-year-old lady is described. Bone formation in BCCs is an uncommon event. We revised the 23 cases described in the literature: most of them occurred on the face. The pathophysiological mechanism responsible for ossification in cutaneous lesions remains unclear. The bone often develops adjacent to, or within hair follicles. We evaluated the immunohistochemical expression in the present case of Cbfa1/Runx2, an early marker for osteoblastic progenitor cells. A well-developed lamellar bone with adipose bone marrow was observed both in the superficial stroma and intratumourally. Cbfa1/Runx2 was localised in the osteocytes of the heterotopic bone and in the keratin cysts of the BCC. The expression of Cbfa1/Runx2 in the present BCC suggests a possible role of this protein in the induction of the heterotopic bone.
本文描述了一例 77 岁老年女性眼睑内发生肿瘤内骨形成的基底细胞癌（BCC）病例。BCC 中的骨形成是一种不常见的现象。我们复习了文献中描述的 23 例病例：大多数发生在面部。导致皮肤病变骨化的病理生理机制尚不清楚。骨通常在毛囊附近或内部形成。我们评估了本病例中 Cbfa1/Runx2 的免疫组织化学表达，Cbfa1/Runx2 是成骨细胞祖细胞的早期标志物。在浅表基质和肿瘤内均观察到发育良好的板层骨和脂肪骨髓。Cbfa1/Runx2 定位于异位骨的骨细胞和 BCC 的角化囊肿中。本 BCC 中 Cbfa1/Runx2 的表达提示该蛋白可能在诱导异位骨形成中起作用。
