Sanke T, Hanabusa T, Nakano Y, Oki C, Okai K, Nishimura S, Kondo M, Nanjo K
First Department of Medicine, Wakayama University of Medical Science, Japan.
Diabetologia. 1991 Feb;34(2):129-32. doi: 10.1007/BF00500385.
Fasting plasma islet amyloid polypeptide concentrations and their responses to an oral glucose load were determined in non-diabetic control subjects and patients with abnormal glucose tolerance in relation to the responses of insulin or C-peptide. Plasma islet amyloid polypeptide was measured by radioimmunoassay. In the non-diabetic control subjects, fasting plasma islet amyloid polypeptide was 6.4 +/- 0.5 fmol/ml (mean +/- SEM) and was about 1/7 less in molar basis than in insulin. The fasting islet amyloid polypeptide level rose in obese patients and fell in patients with Type 1 (insulin-dependent) diabetes mellitus. In non-obese patients with impaired glucose tolerance and Type 2 (non-insulin-dependent) diabetic patients without insulin therapy, the level was equal to that of the control subjects, but a low concentration of islet amyloid polypeptide relative to insulin or C-peptide was observed in the non-obese Type 2 diabetic group. The patterns of plasma islet amyloid polypeptide responses after oral glucose were similar to those of insulin or C-peptide. However, compared to non-obese patients, a hyper-response of islet amyloid polypeptide relative to C-peptide was noted in obese patients who had a hyper-response of insulin relative to C-peptide. This study suggests that basal hypo-secretion of islet amyloid polypeptide relative to insulin exists in non-obese Type 2 diabetes and that circulating islet amyloid polypeptide may act physiologically with insulin to modulate the glucose metabolism.
在非糖尿病对照受试者和糖耐量异常患者中，测定了空腹血浆胰岛淀粉样多肽浓度及其对口服葡萄糖负荷的反应，并与胰岛素或C肽的反应进行了比较。采用放射免疫分析法测定血浆胰岛淀粉样多肽。在非糖尿病对照受试者中，空腹血浆胰岛淀粉样多肽为6.4±0.5 fmol/ml（平均值±标准误），摩尔浓度比胰岛素低约1/7。肥胖患者空腹胰岛淀粉样多肽水平升高，1型（胰岛素依赖型）糖尿病患者空腹胰岛淀粉样多肽水平降低。在糖耐量受损的非肥胖患者和未接受胰岛素治疗的2型（非胰岛素依赖型）糖尿病患者中，该水平与对照受试者相当，但在非肥胖2型糖尿病组中观察到相对于胰岛素或C肽的胰岛淀粉样多肽浓度较低。口服葡萄糖后血浆胰岛淀粉样多肽反应模式与胰岛素或C肽相似。然而，与非肥胖患者相比，胰岛素相对于C肽反应亢进的肥胖患者中，胰岛淀粉样多肽相对于C肽反应亢进。本研究表明，非肥胖2型糖尿病患者存在相对于胰岛素的胰岛淀粉样多肽基础低分泌，循环中的胰岛淀粉样多肽可能与胰岛素在生理上共同作用以调节葡萄糖代谢。
