Karaduman M, Bilici A, Ozet A, Sengul A, Musabak U, Alomeroglu M
Department of Internal Medicine, Etimesgut Military Hospital, Ankara, Turkey.
J BUON. 2010 Apr-Jun;15(2):369-72.
High leptin serum levels, overexpression of leptin and its two main receptor isoforms, OBR-L and OBR-S, have been documented in breast cancer patients. In the present study, the relationship between tissue leptin levels and breast cancer was evaluated.
Thirty-three normal breast tissue samples and 33 breast cancer tissue samples from 33 patients with breast cancer were evaluated. The association of tissue leptin levels and important prognostic factors related to breast cancer was analyzed.
Mean tissue leptin levels in breast cancer tissue samples (5.02 + or - 1.06 pg/ml) were significantly higher than those found in normal breast tissue (2.02 + or - 0.83 pg/ml; p=0.01). No correlation was found in tissue leptin levels and menopausal status, hormone receptor and HER-2/neu status, lymph node involvement, and histopathologic features.
High leptin levels were significantly higher in breast cancer tissue compared with normal tissue. No special correlation was found between tissue leptin levels and different clinicopathological characteristics.
乳腺癌患者血清瘦素水平升高、瘦素及其两种主要受体亚型OBR-L和OBR-S的过表达已得到证实。在本研究中，评估了组织瘦素水平与乳腺癌之间的关系。
对33例乳腺癌患者的33个正常乳腺组织样本和33个乳腺癌组织样本进行评估。分析了组织瘦素水平与乳腺癌相关重要预后因素的关联。
乳腺癌组织样本中的平均组织瘦素水平（5.02±1.06 pg/ml）显著高于正常乳腺组织中的水平（2.02±0.83 pg/ml；p=0.01）。未发现组织瘦素水平与绝经状态、激素受体及HER-2/neu状态、淋巴结受累情况和组织病理学特征之间存在相关性。
与正常组织相比，乳腺癌组织中的瘦素水平显著更高。未发现组织瘦素水平与不同临床病理特征之间存在特殊相关性。
