University of Siena School of Medicine, Department of Neuroscience, Viale Bracci 1, 53100 Siena, Italy.
Expert Opin Pharmacother. 2010 Sep;11(13):2199-220. doi: 10.1517/14656566.2010.507630.
This review addresses practical clinical issues related to the use of ziprasidone in the treatment of schizophrenia using information from clinical trials, unpublished data, manufacturer's information, and input from an expert faculty of European psychiatrists with extensive experience of the use of ziprasidone, both in clinical trials and in everyday clinical practice.
A Medline search of published data (1998 - 2010) was carried out, together with a review of unpublished data and manufacturer's information. In addition, expert opinion was sought from psychiatrists with extensive experience of ziprasidone in the treatment of schizophrenia in clinical settings across Europe.
This review has been undertaken to determine how the information from clinical trials can be optimally translated into 'real-life' practice and to establish how a decade of experience with ziprasidone in clinical practice can inform its optimal use to maximize effectiveness and minimize side effects.
Effective use of ziprasidone in everyday clinical practice usually requires rapid titration to doses in the range of 120 - 160 mg/day and administration with proper meals, thereby achieving the high levels of schizophrenia symptom control reported in clinical trials. Additional guidance is provided about effective management of side effects, and appropriate coadministration of benzodiazepines and other agents, to achieve desired outcomes.
本综述通过来自临床试验、未发表数据、制造商信息的资料，以及对来自欧洲精神病学家专家团的意见的综合分析，该专家团在临床试验和日常临床实践中对使用齐拉西酮治疗精神分裂症有着丰富的经验，来解决与齐拉西酮治疗精神分裂症的使用相关的实际临床问题。
对已发表的数据（1998-2010 年）进行了 Medline 检索，并对未发表数据和制造商信息进行了回顾。此外，还向在欧洲各地临床环境中治疗精神分裂症方面有丰富齐拉西酮使用经验的精神病学家征求了专家意见。
本综述旨在确定如何将临床试验信息最佳转化为“实际实践”，并确定在临床实践中使用齐拉西酮十年的经验如何为其最佳使用提供信息，以最大限度地提高疗效和最小化副作用。
在日常临床实践中有效使用齐拉西酮通常需要快速滴定至 120-160mg/天的剂量，并与适当的膳食一起服用，从而实现临床试验中报告的高水平精神分裂症症状控制。还提供了有关有效管理副作用以及适当联合使用苯二氮䓬类药物和其他药物以实现预期结果的指导。
