论化学合成的范围：从学术实验室创建一个小型管道。
On the reach of chemical synthesis: creation of a mini-pipeline from an academic laboratory.
机构信息
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA.
出版信息
Angew Chem Int Ed Engl. 2010 Aug 16;49(35):6032-56. doi: 10.1002/anie.201000775.
PMID:20661969
Abstract
In this retrospective, we recall some select cases of synergy between very challenging chemical synthesis and the identification of promising new candidates for pharmaceutics development. The progression from targets, often referred to as small molecules, to those of a size commonly associated with biologics (including glycoproteins) is also charted.
摘要
在这篇回顾中，我们回忆了一些非常具有挑战性的化学合成与药剂学开发中具有前景的新候选物的鉴定之间协同作用的精选案例。从通常被称为小分子的靶标到通常与生物制品（包括糖蛋白）相关的大小的靶标的进展也进行了阐述。
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