局部气管内使用丝裂霉素C作为复发性喉气管狭窄内镜治疗的辅助治疗方法。
Topical endotracheal mitomycin C as a complementary treatment for endoscopic treatment of recurrent laryngotracheal stenosis.
作者信息
Cortés de Miguel S, Cabeza Barrera J, Gallardo Medina M, Cassini Gómez de Cádiz L F, Salmerón-García A, Rodríguez Lucas F
机构信息
Servicio de Farmacia, Hospital Universitario San Cecilio, Granada, España.
出版信息
Farm Hosp. 2011 Jan-Feb;35(1):32-5. doi: 10.1016/j.farma.2010.04.002. Epub 2010 Dec 16.
OBJECTIVE
To describe the preparation of topical endotracheal mitomycin C and the clinical outcomes of four patients with recurrent and severe laryngotracheal stenosis (LTS) treated with adjuvant topical mitomycin C.
METHOD
Literature review to determine the concentration and method of preparation of topical mitomycin C for endotracheal use. Review of clinical histories.
RESULTS
We established a concentration of 0.4 mg/ml topical mitomycin C for the treatment of laryngotracheal stenosis. In the treated cases, we applied a 0.4 mg/ml solution to the wound site following laser surgery and dilatation with bronchoscope. Three patients remain asymptomatic from a respiratory perspective, and treatment failed in one case.
CONCLUSIONS
LTS treatment is complex due to the continuous development of granulation tissue and fibrosis following injury to the airways. Topical mitomycin C seems to be the ideal adjuvant agent thanks to its powerful antifibrotic effects.
目的
描述局部气管内使用丝裂霉素C的制备方法，以及4例复发性严重喉气管狭窄（LTS）患者接受辅助局部使用丝裂霉素C治疗的临床结果。
方法
进行文献综述以确定气管内使用的局部丝裂霉素C的浓度和制备方法。回顾临床病史。
结果
我们确定了用于治疗喉气管狭窄的局部丝裂霉素C浓度为0.4mg/ml。在治疗的病例中，我们在激光手术和支气管镜扩张后将0.4mg/ml的溶液应用于伤口部位。从呼吸角度来看，3例患者无症状，1例治疗失败。
结论
由于气道损伤后肉芽组织和纤维化的持续发展，LTS的治疗很复杂。局部丝裂霉素C因其强大的抗纤维化作用似乎是理想的辅助药物。
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