From the Departments of Obstetrics and Gynecology, Pathology, and Plastic Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Obstet Gynecol. 2010 Aug;116 Suppl 2:510-512. doi: 10.1097/AOG.0b013e3181da0266.
The vulva is an extremely rare site for lymphangioma, a benign tumor of the lymphatic vessels. A small number of case reports have described cavernous lymphangioma involving the unilateral labium majus of young women. We report a case of cavernous lymphangiomas involving the bilateral labia minora.
A 14-year-old girl presented with bilateral tumors of the labia minora, which were removed surgically and histologically diagnosed as cavernous lymphangioma. Positive nuclear staining for estrogen and progesterone receptors was demonstrated in the stromal fibroblasts immunohistochemically.
It is suggested that an increase in estrogen and progesterone levels may have led to, or at least affected, the development of these tumors in this patient. Excision followed by cosmetic repair may be the optimal treatment.
外阴是淋巴管瘤的罕见部位，淋巴管瘤是一种良性淋巴管肿瘤。少数病例报告描述了累及年轻女性单侧大阴唇的海绵状淋巴管瘤。我们报告一例累及双侧小阴唇的海绵状淋巴管瘤。
一名 14 岁女孩出现双侧小阴唇肿瘤，手术切除并组织学诊断为海绵状淋巴管瘤。免疫组织化学显示间质成纤维细胞中雌激素和孕激素受体呈阳性核染色。
提示该患者的这些肿瘤可能是由于雌激素和孕激素水平增加所致，或者至少受到了其影响。切除后进行美容修复可能是最佳治疗方法。
