Reimann-Berg N, Willenbrock S, Murua Escobar H, Eberle N, Gerhauser I, Mischke R, Bullerdiek J, Nolte I
Small Animal Clinic and Research Cluster REBIRTH, University of Veterinary Medicine Hannover, Bünteweg 9, Hannover, Germany.
Cytogenet Genome Res. 2011;132(1-2):16-21. doi: 10.1159/000317077. Epub 2010 Jul 29.
Besides man, the dog is the only known mammalian species that spontaneously develops carcinomas of the prostate with considerable frequency. For this reason, the dog is considered to be the only useful animal model for spontaneously occurring prostate malignancies in man. Cytogenetic investigations of human prostate cancers have revealed the frequent occurrence of trisomies 7, 8, and 17. Chromosome analyses of canine prostate carcinomas are rare. In this report we present 2 cases of canine prostate cancer showing a clonal polysomy 13 along with complex karyotype changes. Along with a previous report demonstrating polysomy 13 as the only karyotype deviation in a canine prostate cancer the present report supports the hypothesis that in canine prostate cancer, polysomy 13 is a recurrent cytogenetic aberration linked to the development of the disease. As human chromosomes (HSA) 8q and 4q and the canine chromosome (CFA) 13 share high homology, these results suggest that a conserved area on these chromosomes is involved in tumorigenesis in both species.
除人类外，狗是唯一已知会频繁自发发生前列腺癌的哺乳动物物种。因此，狗被认为是人类自发性前列腺恶性肿瘤唯一有用的动物模型。对人类前列腺癌的细胞遗传学研究显示，三体性7、8和17频繁出现。对犬前列腺癌的染色体分析很少见。在本报告中，我们呈现了2例犬前列腺癌病例，显示出克隆性多体性13以及复杂的核型变化。连同之前一份证明多体性13是犬前列腺癌中唯一核型偏差的报告，本报告支持了这样的假说，即在犬前列腺癌中，多体性13是与疾病发展相关的复发性细胞遗传学畸变。由于人类染色体（HSA）8q和4q与犬染色体（CFA）13具有高度同源性，这些结果表明这些染色体上的一个保守区域参与了两个物种的肿瘤发生。
